Peptide Science & Research Portfolio
Comprehensive analytical guide detailing primary mechanisms of action, scientific research objectives, and standardized laboratory handling protocols for American Top Lab research compounds.
Active Synthesis & Research Compounds
Displaying active verified compounds with batch traceability, HPLC purity specs, and dual-layer security PINs.
TB-500 (Ac-LKKTETQ)
• Target: Actin Regulation & Cell Migration1. What It Does (Mechanism)
TB-500 is a synthetic fraction of the naturally occurring actin-sequestering protein Thymosin Beta-4. It binds to monomeric G-actin, regulating cellular structural cytoskeleton re-organization and promoting rapid endothelial cell migration.
2. Why It Is Studied
- • Endothelial cell recruitment and blood vessel formation.
- • Myofibrillar regeneration and muscle fiber remodeling.
- • Cytoprotective reduction of oxidative inflammation markers.
3. Lab Preparation Protocol
Reconstitution: Slowly trickle bacteriostatic solvent; swirl gently until clear crystal dissolution occurs. Storage: Store cold at 2°C – 8°C. Avoid frequent freeze-thaw cycles.
5-Amino-1MQ
• Selective Nicotinamide N-Methyltransferase (NNMT) Inhibitor1. What It Does (Mechanism)
5-Amino-1MQ is a small-molecule, membrane-permeable selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme predominantly expressed in adipose tissue that impairs cellular energy metabolism. By blocking NNMT, 5-Amino-1MQ increases intracellular NAD+ levels and SAM (S-adenosylmethionine) concentrations, stimulating cellular energy expenditure, enhancing mitochondrial function, and promoting adipose tissue fat oxidation without affecting the central nervous system.
2. Why It Is Studied
- • Investigation of cellular metabolic reprogramming and energy expenditure.
- • Study of adipose tissue lipid metabolism and adipogenesis suppression.
- • Exploration of intracellular NAD+ salvage pathways and mitochondrial biogenesis.
- • Assessment of muscle stem cell proliferation and regenerative capacity.
- • Evaluation of insulin sensitivity and glycemic control mechanisms.
3. Lab Preparation Protocol
Reconstitute using bacteriostatic water or sterile DMSO/saline solution depending on the research protocol. Swirl gently to dissolve completely; avoid aggressive vortexing. Store lyophilized powder at -20°C. Following reconstitution, store in an airtight container at 2–8°C protected from light, and utilize within 30 days.
MOTS-C
• Mitochondrial-Derived Peptide (MDP) / AMPK Activator1. What It Does (Mechanism)
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded within the mitochondrial genome. It functions as a key metabolic signaling regulator that targets skeletal muscle and liver cells. MOTS-c directly enhances the folate-methionine cycle and promotes the phosphorylation of AMP-activated protein kinase (AMPK), stimulating cellular glucose uptake, improving systemic insulin sensitivity, and regulating lipid homeostasis and exercise-mimetic adaptive responses.
2. Why It Is Studied
- • Investigation of cellular metabolic reprogramming and insulin sensitization.
- • Exploration of AMPK pathway activation and mitochondrial biogenesis.
- • Study of skeletal muscle glucose uptake and endurance capacity.
- • Assessment of age-related metabolic decline and cellular longevity pathways.
- • Evaluation of adipose tissue lipid oxidation and weight regulation mechanisms.
3. Lab Preparation Protocol
Reconstitute gently with bacteriostatic water by allowing the diluent to run down the inside wall of the vial. Do not shake or vortex vigorously; swirl gently until completely dissolved. Store lyophilized powder sealed at -20°C. Following reconstitution, store immediately at 2–8°C away from light and do not freeze. Use within 20–30 days.
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